Mathematical Oncology Projects
Impact of Extracellular Vesicles on CAR-T Therapy
Glioblastoma is a highly aggressive brain tumor that is notoriously difficult to treat, with many therapies proving ineffective. One of the challenges in treating glioblastoma is that Chimeric Antigen Receptor T-Cells (CAR-T) therapies have limited efficacy due to the blood-brain barrier and the immunosuppressive tumor microenvironment. The goal of my project was to investigate how Extracellular Vesicles (EVs) might enhance the effectiveness of CAR-T cells and to develop mathematical models to explore the potential of combining EVs with CAR-T therapy as a novel treatment strategy.
Hallmark of Cancer
Hanahan, D., & Weinberg, R. A. (2000). The hallmarks of cancer. Cell, 100(1), 57–70.
https://doi.org/10.1016/S0092-8674(00)81683-9
Hanahan, D., & Weinberg, R. A. (2011). Hallmarks of cancer: The next generation. Cell, 144(5), 646–674.
https://doi.org/10.1016/j.cell.2011.02.013
Hanahan, D., & Weinberg, R. A. (2022). Hallmarks of cancer: New dimensions. Cancer Discovery, 12(1), 31–46.
https://aim.clinic/wp-content/uploads/2023/09/hallmarks-of-cancer-new-dimensions.pdf